Authors: Zoltán Sarnyai, Christopher M Palmer.
Reference:
Ketogenic Therapy in Serious Mental Illness: Emerging Evidence.
International Journal of Neuropsychopharmacology, Vol. 23, Issue 7, 2020, pp. 434–439.
DOI: https://doi.org/10.1093/ijnp/pyaa036
Overview:
The scientific evidence reviewed by Sarnyai and Palmer indicates that the ketogenic approach is emerging as a promising area of research for exploring the modulation of biological processes associated with complex mental health imbalances, particularly in psychosis and schizophrenia. Preclinical studies in animal models show that nutritional ketosis is associated with the reversal of behavioral alterations similar to those observed in schizophrenia, as well as improvements in sensory gating and the modulation of metabolic and neural pathways related to NMDA receptor function and mitochondrial activity.
In addition, the literature includes case reports in which significant reductions in psychotic symptoms were observed in patients with treatment-resistant disorders, along with improvements in weight, energy levels, and daily functioning. The recurrence of symptoms after discontinuation of the diet and their subsequent remission upon reintroduction suggests a potential biological relationship, although the authors emphasize that these findings should be interpreted with caution.
Although the results are encouraging, the article highlights the need for controlled clinical trials to confirm efficacy, safety, and mechanisms of action in broader populations.